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The algorithm, called Helios, was used to analyze a combination of genomic data and information generated by functional RNAi screens, enabling them to predict several dozen new SCNA drivers of breast cancer.
The major drivers of breast cancer risk are 17ß-estradiol (E2) and progesterone (P4).
Perturbations in estrogens and androgens, critical drivers of breast and pubic hair development, remain clinically more challenging to detect [ 31].
Sjoblom et al. (2006) account for nucleotide and dinucleotide context in searching for drivers of breast and colorectal cancer.
The combination of rare or unique somatic events into pathways has identified, and will likely continue to identify, drivers of breast cancer.
Breast Cancer Associated gene 2 (BCA2) was first identified in an effort to investigate drivers of breast cancer via the subtractive hybridization [ 1].
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The mammalian target of rapamycin (mTOR) pathway is a driver of breast tumorigenesis.
Luo, H., Tu, G., Liu, Z. & Liu, M. Cancer-associated fibroblasts: a multifaceted driver of breast cancer progression.
Together, these findings demonstrate PDEF to be an oncogenic driver of breast cancer and a biomarker of poor prognosis in this cancer.
Estrogen receptor α (ER) is a major driver of breast cancer and the target of endocrine therapy.
Our previously published work in a preclinical breast cancer model showed that integrin α3β1 promotes expression of cyclooxygenase-2 (COX2/PTGS2), a known driver of breast cancer progression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com