However, only subjects with known drug testing results were included in this study and results from the sensitivity analyses, including multiply imputed drug testing results for excluded drivers, were consistent with those from the actual testing data.
The major cost drivers were consistent with the findings in our primary analysis.
These cost increases and cost drivers are consistent with the data reported by Lentine et al. 10 Although our study sample represents those patients who actively sought health care, our analysis shows that a sizeable proportion of ADPKD patients seek care early, when signs and symptoms may not have been present.
In this sample, younger drivers were more likely to report ≥1 police stop as a driver in the past 12 months (25% versus 11% for older drivers), which is consistent with findings from a prior, smaller ED sample (20% for younger versus 4.1% for older drivers; (Betz and Fisher [2009]).
During night driving, our results showed a significantly higher ROI DWELL on the task relevant ROIs for both age groups and a lower ROI DWELL on environment in younger drivers, which is consistent with existing literature [ 8, 49, 50].
SPURGEON: Yes, the great drivers are consistent, too, remember.
Indeed, characterization of BCL2L1 as a driver mutation on chromosome 20q is consistent with this notion (Avery et al., 2013), and a number of studies showed a reduced apoptotic response of culture adapted cells (Avery et al., 2013; Herszfeld et al., 2006; Yang et al., 2008).
(61) The existence of several driver mutations in individual cancer is consistent with the hallmarks of cancer.
For instance, increased grey matter in the posterior hippocampi of taxi drivers (Maguire et al. 2000) is consistent with functional imaging data showing bilateral activation of the hippocampi during navigational tasks (Maguire et al. 1998).
Cytidine-to-thymidine transition frequency has not been addressed by the two exome sequencing studies of uveal melanoma (Harbour et al, 2013; Martin et al, 2013) but the complete lack of overlap among the driver mutations in the two pathologies is consistent with a different aetiology.
