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Other studies have supported a mechanism that involves specific interactions between FACT and H2A-H2B dimers as central drivers for alterations in DNA-histone interactions conducive to transcription elongation (Winkler et al. 2011; Hondele et al. 2013; Hsieh et al. 2013).
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Given the transcriptional-level effects observed both herein and by Maglich et al., it is likely that such a mechanism would be complimentary, not alternate, to any transcriptional level control; indeed, the altered protein levels resulting from degradation rate increases might actually be the driver for an alteration in transcription rates, but further work would be required to evaluate this.
Moreover, employing the sets of significant targets of driver TFs, I search for other connected drivers whose alterations result in the misregulation of significantly overlapping sets of genes.
This paper proposes a modeling framework able to analyze the alterations in watershed hydrology induced by two recurrent drivers for hydrological changes: climate change and urbanization.
These driver genetic alterations (for example, mutations, amplifications and fusion genes) have the potential of being exploited as therapeutic targets.
I went sheepishly to ask for alterations, and sometimes I got alterations without asking.
The Drapery Exchange can make recommendations for alterations and installations.
Seamstress available for alterations; reasonable prices.
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Plan for alterations.
Leave space for alterations.
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