Sentence examples for driver of response from inspiring English sources

By convention, established PK/PD analysis methods/models assume that concentration is the main driver of response.

Xie et al. [ 60] applied such a model to predict diarrhoea after receiving irinotecan using AUC as a driver of response.

Henin et al. [ 61] developed a proportional odds ratio model with a Markov process to predict HFS in patients receiving capecitabine using cumulative dose as a driver of response.

In this review, we have listed the currently identified PD drivers of response and predictors of OS for oncology drugs and their cancer indication (Tables 4).

Therefore, while alterations in specific RAS pathway components have lead to an increased understanding of the molecular drivers of response to EGFR inhibition in colorectal cancer, the relationship between KRAS mutation, RAS pathway dependence, and drug response is less clear in NSCLC and other tumor types.

These findings highlight the importance of better understanding heterogeneity in the specific drivers of responses to health risk information.

Whilst participants who thought principally about their function when answering TQs tended to have concordant TQ and RMDQ responses, consideration of pain before function, the predominant pathway, was associated with having a less optimistic TQ response than RMDQ score, suggesting that pain is the primary driver of the response to the daily tasks TQ as well as for the LBP TQ.

Spatial and temporal variability in extreme rainfall, and its interactions with land cover and the drainage network, is an important driver of flood response.

There is good evidence that CCNE1 is the correct call since Cyclin E is a key cell cycle protein and its amplification and over expression has been previously identified as a key driver of patient response to chemotherapy in serous ovarian carcinoma [14].

For example, RSC3 is a member of a chromatin-remodeling complex and interacts with YAP1, a driver of menadione response.

Integrin β1 signalling was an integral driver of this response, via Fak, Erk, Pkb/Akt and Stat3 pathways [ 40].