The analysis of transcriptional responses following injury is a powerful approach to identifying candidate drivers of heart repair and regeneration, which may represent potential targets for triggering or boosting cardiomyocyte renewal in mice and humans [ 29, 30].
These results identify (i) novel mechanisms for ameliorating genetic heart disease, (ii) metabolic and inflammatory discrepancies between a genetic cardiomyopathy and other drivers of heart failure, (iii) putative sources of the clinical heterogeneity associated with HCM, and (iv) the importance of crosstalk between the heart and liver during the progression of primary genetic heart disease.
Chronic inflammation is a known driver of killers like heart disease and cancer.
Unless you can show that the other driver had a history of heart problems and should not have been driving (almost impossible), his insurer (the Co-operative) can refuse to pay your claim.
One seminal set of studies of London bus drivers and conductors showed that the sedentary bus drivers had higher rates of heart disease than the ticket takers, who moved around during the workday.
While the driver had a medical history of heart issues, the heart attack was unforeseen.
Reduction of recurrent hospitalization for worsening HF is extremely important, as HF admissions are not only distressing for patients and their families, but also significantly affect patients' quality of life and are the major driver of the economic burden of heart failure.
In terms of absenteeism, low back pain is the main driver in both jurisdictions, and for productivity loss due to premature mortality the primary driver of cost is coronary heart disease.
The finding that sedentary bus drivers had much higher rates of heart disease than the active conductors who rushed up and down the steps of the double-decker had all Jerry's qualities of imaginative epidemiological research design.
A major driver of myofibroblast apoptosis in the heart and other tissues is thought to be a release from mechanical stress [ 42].
