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Epigenetics is an important driver of gene expression and hence it has a direct effect on the phenotype.
For 24 hour samples, the primary driver of gene expression profiles was geographic location, regardless of the treatment temperature at which they were raised.
That only six controls and five AS samples were misclassified indicates the major driver of gene expression as disease status.
This suggests that the mating treatment was the major driver of gene expression in the honey bee brain.
This suggests that the GMR-3xP3 promoter is a strong driver of gene expression and that the ZsGreen and AmCyan fluorescent proteins can be used as markers in insects.
The results indicated that diurnal rhythm was the most significant driver of gene expression variation in the human adipose tissue, with at least 25% of the genes having had significant changes in their expression levels during the course of the day.
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Inflammation profiles highlighted monocytes, macrophages and dendritic cells as key drivers of gene expression patterns associated with high fat diet in liver.
A common method for finding drivers of gene expression is to look for transcription factor binding sites in the promoters of the genes.
First, our purpose is focused on identifying relationships between gene expression and environmental conditions while Nagano et al. are investigating all possible drivers of gene expression in order to be able to predict gene expression.
The MMBN provides directional information about the relationship of gene expression and can be used as a tool for identification of the key drivers of gene expression signatures characterising various phenotypes [ 23].
Finally, the combined expression and genetic approaches pointed to putative cis-drivers of gene expression programs in skeletal muscle as COQ4 (SSC1), LOC100513192 (SSC18) where both the gene transcription unit and the eQTL affecting its expression level were shown to be localized in the same genomic region.
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