Altogether, it seems that MP itself, however it is generated (whether via bona fide centrosome declustering or acentrosomal spindle pole amplification), is a key driver of cell death in 231 and HeLa cells, although CA may instead be mechanistically involved in cell death in PC3 cells.
It has been hypothesized that reduction of the anti-apoptotic Bcl-2 family member Mcl-1 constitutes the major, possibly even the sole, driver of cell death.
Therefore, the involvement of two separate death signalling pathways in response to thapsigargin may reduce sensitivity to down-regulation of ER-stress chaperones, particularly if a mitochondria-dependent mechanism is a major driver of cell death in response to thapsigargin.
Remarkably, knock down of Bim by siRNA strongly inhibited cell lethality in response to high concentrations (100 nM) of dexamethasone (Fig. 6c), indicating that Bim is a major driver of cell death in this system.
Although some anti-cancer agents can induce autophagy in various types of cancer, it remains controversial as to whether autophagy is in fact the driver of cell death or a pro-survival process in response to drug treatments.
As the cause of more than 2 million child deaths a year, malnutrition is a major driver of child deaths in the developing world.
This panel, reflecting views by most beekeepers and academic experts, concluded that neonics were unlikely to be the major driver of bee deaths.
Mother Jones, in its coverage led by food reporter Tom Philpott, has been particularly myopic in its promotion of Lu's controversial views and the scientifically dubious claim that neonics is the prime driver of bee deaths.
When a teenage driver carried at least one passenger age 35 or older, however, the driver's risk of death was reduced by 62 percent, and risk of involvement in any police-reported crash was reduced by 46 percent, according to the study.
