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GATA3 was included in the driver network for the "differentiated subtype" with relatively good survival outcome, although GATA3 mRNA was not significantly up-regulated in this subtype.
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Therefore, we selected genes from our TNBC driver-networks for functional validation in vitro.
We identified distinct driver-networks for each of the three common clinical breast cancer subtypes: oestrogen receptor (ER)+, human epidermal growth factor receptor 2 (HER2)+, and triple receptor-negative breast cancers (TNBC) from patient and cell line data sets.
The driver-networks for each of the three different clinical subtypes identified through this process from all three data sets (two patient data sets and one cell line data set) are listed in Supplementary Table S3.
If A and B represent sets of driver-network members from different clinical data sets, we calculate the normalised overlap using the formula: where ∣ A∣ denotes the cardinality (number of elements) of set A. We selected 30 genes from the TNBC driver-networks for functional validation that were not previously studied extensively in the context of TNBC.
Motivation: Studying combinatorial patterns in cancer genomic datasets has recently emerged as a tool for identifying novel cancer driver networks.
We also confirmed the functional relevance of a subset of randomly selected driver-network members for TNBC in gene knockdown experiments in vitro.
For example, the MYB-ASH2L and CLTC-AP1G1 satellite subnetworks were present in ER+ driver-networks from both patient data sets.
Giles Dilnot reports on the "government drivers' network".
The desire to address these challenges becomes the main driver for network and systems convergence and evolution to a new network and service architecture.
The Waze smartphone app works like a social network for drivers, combining online maps with updates from other drivers about traffic jams, road works and accidents.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

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CEO of Professional Science Editing for Scientists @ prosciediting.com