Sentence examples for driver mutation from inspiring English sources

We investigate the dynamics of cancer initiation in a mathematical model with one driver mutation and several passenger mutations.

Transcribed gene fusions are key biomarkers in many hematologic and solid tumors, often representing the primary oncogenic driver mutation.

Only when the driver mutation occurs in one of those cells, the cell population starts to grow rapidly.

Driver mutations can also occur later in clonal evolution and infer resistant properties that were not present in the initial driver mutation.

The known anti-apoptotic role of BCL-XL isoform (Boise et al., 1993) made this gene the prime candidate as a driver mutation in the 20q11.21 region.

The KRAS mutation remains the most common driver mutation in patients with non-small cell lung cancer (NSCLC) and confers a poor prognosis.

The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRasG12D, which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM).

First, generally, a driver mutation is rare.

This sample harbors the aforementioned driver mutation BRAF L597.

This is a known driver mutation in human colorectal tumours.

The model dynamics depends on only three parameters: namely the driver mutation rate (u), the selective advantage associated with driver mutation (s), and the cell division time (T).