Sentence examples for driver event from inspiring English sources

The riverhead is analogous to the trunk mutation, originating with a ubiquitous driver event.

Loss of p120ctn is a pro-tumorigenic driver event in epithelial cancers with augmentation of EGFR signaling in breast cancer, elevated levels and activation states of c-Src kinase and FAK have been found to be associated with accelerated progression and shorter survival in epithelial malignancies including gastric cancer [31 33].

The authors specifically identified NF1 as an important driver event in oncogene-negative adenocarcinoma.

However, causes of genomic instability remain to date unclear thus failing identification of universal driver event in MM cells.

Alterations concentrating around a common function suggests that altering this function can be a driver event for the cancer.

Moreover, ERG overexpression is considered a PC "driver" event whether caused by translocation, copy number alteration, or other mechanisms [ 56].

We performed large-scale genome sequencing analyses on BTCs to investigate their somatic and germline driver events and characterize their genomic landscape.

Uncovering and dissecting true driver events in MM might provide rational for new potential targets and therapeutic option in the disease.

The new paradigm of mutations in chromatin-modifying genes as driver events in the development of cancers has proved challenging to resolve the complex influences over disease phenotypes.

The classical myeloproliferative neoplasms (MPN) are comparatively uncommon in children and display a degree of mutational naivety if considering the high frequency of known MPN driver events observed in the corresponding adult diseases.

These findings coupled with the diverse (sub clonal evolution trajectory followed by CLL cells, at least in treated patients, alludes to their role as major subclonal driver events for disease progression.