Sentence examples for driver candidates from inspiring English sources

First, the network-based approach identifies many of the same driver candidates as the original TCGA frequency-based approach used to assess mutational significance.

We identified three new driver candidates not present in previous publications: AQP7, MEF2A and UBC.

Importantly, DOTS-Finder has confirmed the predictions made by other methods and discovered novel driver candidates never identified before.

Typically, the functional information is missing or poorly understood for new driver candidates and the genetic information (allelic-specific) is not directly available in cancer sequencing studies.

Drivers Recurrence in genome : for each of the driver candidates identified in the previous tabs, shown are the occurrence of a driver mutation in that ORF across each of the patient series.

And while recurrence is often the surrogate measure of functional importance, the four unique driver candidates from this 15 patient sample still contain features associated with oncogenic gene fusions.

For example, within the PIK3R1 module, the most notable new driver candidate is AGAP2, a gene which has been previously implicated in human glioblastoma [36], but was not reported in the first TCGA pathway analysis [4].

Second, any gene that disrupts a driver pathway is considered to be a driver candidate; therefore a driver pathway need not be dominated by the mutation of a single gene.

Five of the six Jones et al.-ranked driver candidate genes (TP53, CDKN2A, KRAS, TGFBR2, SMAD4) were represented in the top 500 MeSHOP predictions; MeSHOP comparisons did not identify the sixth gene, MLL3.

These samples constitute approximately 10% of the population; our driver candidate predictions are reported in Table S4 in Additional file 2. At the top of the list of predicted OGs is EGFR, consistent with the fact that EGFR is a key oncogenic player in never smokers with LUAD.

In a second cross-validation analysis set up to estimate the reproducibility of the results, we excluded 20%% of the samples at random and re-ran the entire analysis 10 times for a set of 20 selected top driver candidate genes.