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Fundamental knowledge derived from the study of joint development and homeostasis has driven the identification of promising targets for OA treatment.
More recently, cartilage developmental biology has driven the identification of new stimuli suitable for use in the self-assembling process, toward better enhancing the mechanical and biochemical properties of engineered neocartilage.
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The improved breakpoint delineation drove the identification of novel disease gene NEO1 which conferred aetiological importance in ASD [29].
Capturing this inhibitory mechanism could fuel the design of more effective inhibitors at the NNRTI site and also drive the identification of novel allosteric sites.
The approach, which also provides broad target selectivity information, was used to drive the identification of a potent and orally active Hsp90 inhibitor, SNX-5422, which is currently in phase 1 clinical studies.
Good practice in DCE design is for qualitative work to drive the identification and selection of attributes.
Motif group V showed the highest levels of sequence similarity with group I and drove the identification of four bHLH TFs.
Such progress promises to drive the identification of predictive models of drug response enabling drug delivery governed by the genomic heterogeneity specific to each tumour.
The development process is made up of disparate yet interdependent stages in a critical path that is driven by the identification of end-user needs.
Most of the major findings that have emerged from research on Drosophila were driven by the identification of mutations producing a chosen phenotype via unbiased forward genetic screens.
Knowledge of this interesting and complex receptor glycan has been driven by the identification of a number of disease genes predicted to encode novel glycosyltransferases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com