Notably, alpha-synuclein expression is driven in Tg SNCA 1Nbm/J mice from the human SNCA promoter and in M83- and M20-mice from the hamster Prnp promoter.
Therefore, we tested whether increased Txnip expression could be driven in WT mice by 2DG.
Ongoing insulitis, as a hallmark of T1D in NOD mice, is driven in part by the persistence of activated, autoreactive T and B lymphocytes.
We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice.
BRAF V600E mutation has been clearly shown to drive senescence in mouse models of lung cancer and melanoma, and human nevi express SA β-gal.
Furthermore, studies carried out using rats and mice differ by the model systems used (carcinogen-induced in rats or oncogene-driven in mice) and the differences in mammary gland morphology and oestrogen responsiveness of the established tumours (responsive in rats or non-responsive in mice), which can explain why the data generated in the rat and mouse studies are diverse.
To understand how coactivator proteins regulate response to nuclear hormone receptor ligands such as PPAR and RXR we examined neu oncogene driven mammary tumorigenesis in mice lacking SRC-1.
Translocation of a gut pathobiont drives autoimmunity in mice and humans.
The BRAF V600E activating mutation accounts for approximately 90% of BRAF mutations in melanoma and BRAFV600E drives melanomagenesis in mice (Dhomen and Marais, 2007; Dankort et al, 2009).
Overexpression of TGF-β1 is sufficient to drive progressive fibrosis in mice (Sime et al., 1997) and TGF-β1 has more recently been shown to drive either epithelial cell apoptosis (Yanagisawa et al., 1998) or EMT (Kim et al., 2009) (Willis et al., 2005), depending on the composition of the ECM.
