Sentence examples for driven by relevant from inspiring English sources

A more effective approach would seemingly be to employ multiple GEMMs, each driven by relevant genetic abnormalities that together encompass the full spectrum of molecular variability inherent in these neoplasms.

Increased use of genetically engineered mouse (GEM) models driven by relevant abnormalities such as BRCA mutations, HER2 overexpression and so on have enabled the study of naturally occurring tumours in immunocompetent hosts and evaluation of new targeted therapies such as PARP inhibitors and the emergence of resistance [ 373].

A design strategy to assess these parameters is outlined, driven by the relevant observation that a perfect tuning of the natural frequencies always corresponds, in the parameter space, to the maximum modal damping for one of the resonant modes, independent of the damper model.

Same-store sales rose 4.8% in Europe, helped by strength from France, Russia and the U.K. and driven by locally relevant menu options, McDonald's said.

The goal of the present work is to determine which signal transduction systems are involved in transformation driven by a relevant oncogene.

Some of this is driven by a newly relevant news cycle that has seen American audiences wake up to the day-to-day decisions that are reshaping the country from the halls of power in Congress and the White House.

Our goal was to study the signal transduction mechanisms involved in neoplastic transformation driven by a biologically relevant oncogene.

In conclusion, these data demonstrate that IL-13 neutralisation reduces airway inflammation, normalises baseline lung function and reduces AHR to inhaled spasmogen in a mouse model of asthma driven by a clinically relevant aeroallergen administered by the inhaled route only, and without the use of experimental adjuvants.

Namely, lack of HSF1 expression protected mice against tumorigenesis in a chemically-induced skin carcinogenesis model and in a genetic model driven by a clinically relevant oncogenic mutation in p53 (p53R172H) [ 8].

Practitioners found it useful to participate in JCs that are driven by a question relevant to their day-to-day practice, and which focuses on the appropriateness of applying the findings from critically appraised evidence.

While this is not proven in humans, it is quite intriguing and further supports the relevance of MYC-based prostate cancer models driven by AR as highly relevant to the human disease.