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In order to confirm that endogenous Hipk1 can antagonize Wnt/β-catenin signaling in another system, we used siRNA strategies to knock-down the human HIPK1 ortholog in HEK293T cells, and then assessed Wnt/β-catenin signaling using a β-catenin-dependent reporter plasmid in which luciferase expression is driven by optimal Lef/Tcf promoters [76], [77].
Benefits were driven by optimal allocation of adjuvant chemotherapy and reduction in chemotherapy utilization.
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(8) This optimal trajectory is driven by an optimal realization of the environmental noise.
The model presented supports decision-making process driven by an optimal investment cost and the techno-economic analysis of digital terrestrial wireless technologies using innovation service diffusion Bass model.
These results indicate that the pathways into future energy systems will be driven by an optimal systemic combination of technologies that reduce the system's reliance on backup power and energy.
In a continuous-time setting where a risk-averse agent controls the drift of an output process driven by a Brownian motion, optimal contracts are linear in the terminal output; this result is well-known in a setting with moral hazard and – under stronger assumptions – adverse selection.
This high value is driven by the flexibility to provide optimal amount of FR under different system conditions.
This is driven by the concept of the optimal biological dose (OBD) that, for such targeted therapies, may be well below and more relevant than the maximum tolerated dose.
It is shown that the optimal policy is largely driven by customer heterogeneity: limited heterogeneity in customers' costs leads to very different optimal policies compared to large heterogeneity.
(a) The full megamap with optimal weights is driven by the conflicting external input, (textbf{b} = (1/overline {b_{mathrm{pk}}})(b_{mathrm {pk}}^{1}overline {textbf{b}} textbf{x}_{1}) + b_{mathrm{pk}}^{2}overline {textbf{b}} textbf{x}_{2}))), where (overline {textbf {b}} textbf{x}_{k})) is the training input into location (textbf{x}_{k}) (Eq. (2)).
First we examined the oscillatory state of the solutions in order to see whether the oscillations were driven by the neurotransmitter, as in the optimal parameter set.
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CEO of Professional Science Editing for Scientists @ prosciediting.com