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Glomerular injury of immune origin is complex and involves both inflammatory and non-inflammatory processes driven by elements of the innate and adaptive immune system.
Further supporting these observations, Cdx4 upregulates expression of the reporter driven by the Hoxa9 elements containing CBSs, but not the reporter driven by elements without CBSs (Fig. 5).
The choices should be driven by elements of effective CME outlined above.
This in general would be consistent with a situation where the total level of expression of a gene is driven by elements that are stronger than the effect of the cis acting variant, such as biological feedback loops.
Since reporter constructs driven by elements of the human MMP-1 and MMP-13 promoters often do not mirror expression of the endogenous genes, we shifted to a more direct, in vivo approach, using ChIP assays to detect changes in PPARγ binding at the DR-1/AP-1 site of the endogenous MMP-1 and MMP-13 promoters in genomic DNA.
As such, subtype-specific expression patterns are likely driven by elements contained within the local upstream promoters of individual genes, although this does not preclude the possibility of a locus control region regulating placental-specific for the entire cluster, regulating trophoblast-specific transcriptional access to the whole of the region.
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EM_ element is driven by CR_ elements.
A large portion of structural variation in the mouse genome is driven by transposable elements including short interspersed nuclear elements (SINEs), long interspersed nuclear elements (LINEs) and long terminal repeats (LTRs) [ 11, 12, 16], but these regions are not well captured by array technologies because of the inherent difficulty in designing suitable probes for repetitive elements.
These three clusters also appear to be driven by repetitive elements because when repetitive elements are masked out we observe only two clusters on the human X chromosome, one corresponding to the PAR1 and the other corresponding to the rest of the X chromosome (which is almost entirely nonrecombining in males).
These elements could still be actively driven by autonomous elements if they conserve their LTRs, polypurine tracts (PPTs), and primer binding sites (PBsites
Those differences may explain why occupancy dynamics were driven by distinct elements.
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