These results corroborate findings showing an increase of the coupling state of isolated mitochondria by GBE in ischemia models [31] and findings demonstrating that GBE ameliorated oxygen consumption of mitochondria from rat heart mainly driven by effects of GBE on complex I and III [29].
However, this analysis does not determine whether this signal is driven by effects of one specific genotype.
It is important to note that the significant differences we see between networks are not driven by effects of other sex-related factors.
This finding suggests that associations between diastolic BP and PM2.5 absorbance may have been driven by effects of traffic-emitted PM2.5 components.
PPI seemed to be driven by effects of NZO (+0.5 additive effect to model) and NOD (−0.5 additive), with the most significant epistatic effects coming from NOD crossed with B6 and 129S1 (File S1).
We present evidence that the association between high-copy, short-motif microsatellites and recombination hotspots is not driven by effects on microsatellite distribution of other factors previously linked to both recombination and microsatellites, including transcription, GC-content and transposable elements.
Although the effect of humidity is much less for API 1 than API 2, the dissolution rate drop for both APIs are primarily driven by effect of temperature, which is more significant for API 1 than API 2; therefore, more changes are observed in API 1 than API 2 at the end of the two-year storage and the differences are more pronounced at 30 °C than at 25 °C.
This effect was driven by the effects of the right PFC ROI, F10, 119 = 2.523, P = 0.009, and ηρ = 0.175, as well as the right IPL ROI, F10, 119 = 2.919, P = 0.003, and ηρ = 0.197, whereas no statistically significant effect was present for the a priori chosen MFC ROI.
Our interpretation is that increased P availability, bacterial dominance of nematode trophic channels and graminoid growth are likely driven by direct effects of Pinus, but that these effects may be further augmented by a large influx of leaf litter, fine roots and woody biomass following tree removal.
Nevertheless, after adjusting for PM2.5 in the alternative models, the associations decreased and became nonsignificant (0.41% increase; 95% CI: –0.51, 1.35% for all cause mortality using the PACF, and 0.18% increase; 95% CI: –0.65, 1.01% using the case-crossover approach), thus supporting the possibility that health effects of PM are driven mainly by effects of fine particles.
These results are unlikely to be substantially driven by contemporaneous effects of illness on income because of the restrictions of our sample to individuals with more than one year of follow up who had not ever changed jobs, changed to part-time work, or retired early due to health reasons.
