Sentence examples for driven by alterations from inspiring English sources

In parallel with those observations, many lines of evidence suggest that cancers may be driven by alterations that are epigenetic in nature, that is, they do not alter the primary DNA sequence (McDonald et al, 2011; Timp and Feinberg, 2013).

This rapid relapse is driven by alterations in the Aurora B signaling pathway that hyper-stabilize k-MT attachments and is reversible following UMK57 removal.

Further studies are required to understand the molecular mechanisms driven by alterations in A-type lamins on Rb signaling pathways.

These channels, symporters and exchangers, driven by alterations in K concentration, modulate fluid transfer by controlling the absorption and secretion of chloride [22], and hence water transport, via the cotransporters themselves [24] and in concert with aquaporin channels [19].

Despite inhibition of p53 by Tag in this mouse PNET model, concomitant disruption of Arf via genetic knockout resulted in a significantly accelerated pathway to tumor formation that was surprisingly not driven by alterations in tumor cell proliferation or apoptosis, but rather via earlier activation of the angiogenic switch.

Cancer development is driven by alterations in both genetic and environmental factors.

Consistent with our prediction that attentional training would primarily be driven by alteration of frontal function, no such effect was apparent in the amygdala, even when using an ROI analysis (Supplement 1).

These alterations are thought to be mechanistically driven by epigenetic alterations.

It is critical, therefore, to determine if the increased risk is driven by epigenetic alterations in genes that increase susceptibility to breast cancer and if these alterations are reversible.

It is of critical importance to determine if the increased risk is driven by epigenetic alterations in genes that increase susceptibility to breast cancer and if these alterations are reversible.

However, it has become apparent that cancer is also driven by epigenetic alterations.