However, it remains to be shown whether altered histone modifications can drive altered gene expression later in development.
Although there is evidence to suggest that changes in the steroidogenic enzyme transcriptional profile helps cancer cells to proliferate in the low-T environment, it is unclear what drives altered transcriptional regulation of these genes in CRPC.
Recently, transgenic animals with alterations specifically targeting the urothelium (urothelial restriction or conditional transgenics) have been developed to test the hypothesis that urothelial dysfunction can drive altered bladder function.
Box 2. Could gene drives alter domesticated animals or crops?
Box 1. Could gene drives alter human populations?
Such studies have led to an understanding that induction of HIF-1 responsive genes drives altered cellular metabolism, increased vascular mass and diameter and increased oxygen carrying capacity of the blood; all events which are conducive to an adaptive response to diminished oxygen supply [1], [14] [16].
Change could be driven by altering the requirements for police recruits, he said.
One reviewer mentioned that the book has "quintessential Coupland themes, chiefly, how the speed of change, both technologically and socially driven, is altering the world, our own sense of self and our souls".
Here we utilize modern systems biology in a rodent model of concussive injury to gain a thorough view of the impact of TBI on fundamental aspects of gene regulation, which have the potential to drive or alter the course of the TBI pathology.
The many malignant-like phenotypes observed upon loss of a single polarity regulator must be driven by altered gene expression.
This transition is driven by altering social needs and the wish for a more patient-centred care [ 18, 21, 27].
