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This may take some practice, so you may want to test drive this method on a few hot dogs first.
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With regard to copy-cutting, the recent development of Cas9 variants with broadened PAM specificity21,22 may substantially increase the fraction of alleles that can potentially be driven by this method.
If your car has electric fans (typically front-wheel-drive vehicles), this method will not work for you.
When using an analytical method, defining an analytical target profile (ATP) focused on quantitative performance represents a key input, and this will drive the method development process.
In this study, a step climbing method for a five-wheeled wheelchair was proposed, and an add-on drive mechanism to realize this method was developed.
From dollar drives to bake sales, this method is important since it doubles as a publicity opportunity and can create a strong sense of ownership among contributors.
However, as this was a one to one interview, and the conversation was responsive to the agenda of the interviewee rather than driven by the questions, this method nonetheless generated valuable data.
In this method, the drive wheel climbs along to the side of the step, but a force is required to make the drive wheel contact the side of the step in order to generate the traction force.
New methodologies - This area is about supporting the learning of the student; technology or requirements can drive these methods.
The question drives the method, not the opposite.
Arguably, this method has driven more innovation than any other single intellectual development in all of history; this is true not because it is "open" or "free" or self-consciously "creative," but precisely because it is intentional in how it constrains thinking.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com