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He and some associates drive the cargo to Syria and hand it over to the rebels.
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And the service and propulsion module that drives the cargo capsule through space would be more versatile than the existing ATV unit.
Cellular processes such as morphogenesis and signalling are complex, and regulatory proteins are required to orchestrate and drive the membrane remodelling, cargo sorting and cytoskeletal rearrangements that must occur during such events.
The packaging of an elongated cargo can drive the switch from hemispherical to tubular, just as some variation of membrane tension or other stochastic fluctuation has presumably driven the switch during the in vitro assembly of the coats studied here.
The late-aborted structures therefore correspond to the situation where sufficient PtdIns4,5P2 is present to drive the conformational change but insufficient cargo is available to further stabilize the binding of AP2 to the membrane.
We agree with the reviewers that cargo packaging could drive the switch from spherical to tubular morphology, and that the inner and outer coats could co-assemble, with the inner coat imposing regularity on the outer coat, or vice versa.
One explanation is that cargo drives the formation of specific endocytic compartments.
Conventional SNXs possess a BAR (Bin-Amphiphysin-Rvs) domain, which drives the membrane curvature and cargo segregation into the tubular structure [ 124].
We reveal that stretch-induced strain gradient in graphene leads to a net transport force that is sufficient to drive molecular cargo on the graphene in a directional fashion.
It binds directly to both MAP1LC3B and ubiquitin, and drives the selective degradation of ubiquitinated cargo through the autophagic pathway.
Our clinic for uninsured patients like Carlos was actually a converted cargo van that drove the back alleys of the city, stopping behind big-box stores and beneath bridges to repair cuts and scrapes among the city's homeless population.
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