Sentence examples for drive the altered from inspiring English sources

Cell metabolic reprogramming is one of the main hallmarks of cancer and many oncogenic pathways that drive the cancer-promoting signals also drive the altered metabolism.

Upon JNK inhibition, the diversity of binding motifs was greatly reduced (Fig. 2A) as the number of deregulated genes decreased relative to ras V12scrib clones (Fig. 1A), thus implicating JNK as a master regulator of those TFs that cooperatively drive the altered ras V12scrib tumor transcriptome.

Potentially, increased expression of these genes may be driven by the altered cytokine environment within psoriasis lesions [ 5, 6, 16].

In the uninfected fetuses and newborns, the disruption of the TLR9 signaling pathway, engaged in the induction of type I IFNs, might also be driven by the altered TLR4 molecule.

Several oncogenic mutations have been identified in cutaneous melanoma that may drive the malignant phenotype by altering downstream signaling through the PI3K/AKT/mTOR and MAP kinase pathways to decrease apoptosis 130 and increase cell cycling.

Positive selection on protein-coding genes could raise the non-synonymous substitution rate, as it could drive the fixation of mutations that altered the functional properties of the protein.

Here we utilize modern systems biology in a rodent model of concussive injury to gain a thorough view of the impact of TBI on fundamental aspects of gene regulation, which have the potential to drive or alter the course of the TBI pathology.

If unobserved factors drive the association between ego and alter, then direction of friendship should not be relevant.

If unobserved factors drive the association between ego and alter happiness, then directionality of friendship should not be relevant.

Protocolized cardiovascular management based on functional hemodynamic monitoring has the added advantages of being intuitively obvious (facilitating buy-in by stakeholders), pleuripotential (many different monitoring devices can all drive the same protocol) and scalable (alter intensity of resuscitation), and lends itself to automation.

These data lend further weight to the hypothesis that altered developmental networks drive the pathogenesis of steroid associated bone disease.