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Despite the advances in our understanding of the molecular basis of oral carcinogenesis and of oral cancer therapy, detailed information on the mechanisms that drive stepwise tumor progression is still missing.
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Lack of preparedness meant that 'actions taken by the UK Government and the Government of Montserrat were driven stepwise by events in the volcanic escalation' (Kokelaar 2002: 1).
Instead, Slx9 overcomes the low affinity between the NES and Crm1 and drives stepwise assembly of a Crm1-export complex on the NES-containing adaptor Rio2 of the 40S pre-ribosomal cargo.
Two flexibly linked N-terminal zinc fingers recognize the extreme deformability of SSBs and drive co-operative, stepwise self-assembly of remaining PARP-1 domains to control the activity of the C-terminal catalytic domain.
The QD donor drives energy transfer stepwise through the intermediate nucleic acid dye to the final acceptor Cy5.
One consequence of this evolutionary complexity may be that evolution of salt tolerance is slow and may take place gradually or stepwise, driven by high salinity of the environment.
X-ray films were then digitized using a custom-built scanner equipped with a stepwise driven motor and a line-camera on an incident-light microscope, resulting in a resolution of 3·52 µm pixel−1.
CPH models (ii), (iii), (iv) and (vi) were feature-selected using a forward/backward stepwise heuristic driven by AIC [ 29].
Finally, when fitting model (vi), i.e. feature-selected Cox regression using a forward/backward stepwise heuristic driven by AIC, for both BRCA1/2 sets only the year of birth, all the menopausal age stages (along with ovulating stratum), and the oophorectomy variables were selected in the final model (RH were in line with those obtained from other models).
Fingers were, however, left free for the shrill glissandos and racing stepwise movement.
The stress distribution due to free edge effect could move with the crack front and consequently drove the main crack propagating stepwise.
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