Many oncogenic events were shown to drive proliferation of these myeloid cells (Tefferi and Gilliland, 2007).
The goal is to find particular molecules in a cell that drive proliferation or tumor survival, and to block them.
Goldrath, A.W. & Bevan, M.J. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts.
This developmental process is reversed during prostate tumorigenesis, i.e., Wdr77 is translocated from the nucleus into the cytoplasm to drive proliferation of prostate cancer cells.
Discovery of this novel PRC2-TBX3-TBX2 genetic axis has important implications for understanding the mechanisms that drive proliferation and differentiation in RMS and skeletal muscle.
Thus, Ezh2 coordinates cellular activation and the maintenance of cellular identity by directly responding to extracellular cues that drive proliferation (CD28 co-stimulation) and functioning with lineage specifying transcription factors (Foxp3) to reinforce the cells' transcriptional program.
In RMS, deregulated PRC2 activity leads to constitutive expression of TBX2 which functions to drive proliferation by direct repression of CDKN1A, CDKN2A, and PTEN while inhibiting the activity of MYOD1 and MYOG27.
Toll-like receptor (TLR) and CD40 signaling in T cells can improve persistence and drive proliferation of antigen-specific CD4+ and CD8+ T cells following pathogen challenge or in graft-versus-host disease (GvHD) settings, suggesting that these costimulatory pathways may be co-opted to improve CAR-T cell persistence and function.
Knockdown of p16 INK4A) cooperated with PAX3-FKHR to drive proliferation past senescence, whereas reintroduction of wild-type p16 INK4A) in post-senescent cells caused growth arrest.
This finding was validated both in vitro and in vivo, with EZH2 overexpression proving sufficient to drive proliferation in cancer cells and transform primary fibroblasts (Bracken et al., 2003; Croonquist and Van Ness, 2005).
Following stimulation, T cells produce and use IL-2 in an autocrine fashion which is required to drive proliferation [7].
