Targeted therapies aim to disrupt certain signaling pathways and epigenetic mechanisms that are dysregulated in cancer cells and drive hallmark features such as tumor growth, progression and spread.
True, the Chevrolet Suburban had a similar layout (and a name that dates to the 1930s), but the Suburban didn't acquire four-wheel drive, a hallmark of the S.U.V. category, until 1960; the Travelall was available with four-wheel drive by 1956.
Although China's new president, Xi Jinping, has made an anti-corruption drive a hallmark of his early tenure, human rights groups say that his suppression of the New Citizen's Movement reflects a zero-tolerance attitude towards anything that could threaten the ruling Communist party's grip on power.
A drive-through Hallmark shop would certainly save us all time.
Faced in the early 1990's with slumping sales, the company decided in 1994 to make all-wheel drive the Subaru hallmark.
Essential hallmarks that drive tumorigenesis as described by Hanahan and Weinberg include: self-sufficiency in growth signals; insensitivity to growth-inhibitory (antigrowth) factors; evasion of programmed cell death (apoptosis); limitless replicative potential; sustained angiogenesis; and tissue evasion and metastasis [ 1].
This leads to constitutive activation of KRAS and persistent stimulation of downstream signalling pathways that drive many of the hallmarks of cancer, sustained proliferation, metabolic reprogramming, anti-apoptosis, remodelling of the tumour microenvironment, evasion of the immune response, cell migration and metastasis (Pylayeva-Gupta et al, 2011).
A focus on leveraging creative strategies and partnerships to drive results is a hallmark of Joan's successes, with specializations in innovation, women's advancement, sustainability/clean tech, and thought leadership.
But more often, I have taken the route to go to the Hallmark Drive-In, a landmark in Old Lyme that has sold homemade ice cream for 100 years.
She has never shied away from confrontation in a government that has made discipline and unity its hallmarks in an effort to drive out the divisive politics that left Labor in opposition to Conservatives for 18 years.
