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Therefore, it was speculated that YAP overexpression might be sufficient to drive excessive skeletal muscle formation.
An emerging hypothesis is that individuals who exhibit heightened reactivity to uncertain threat may be especially motivated to use alcohol to dampen their distress, setting the stage for negative reinforcement processes to drive excessive alcohol use.
In other tissues, including liver, muscle and pancreas, high fat diet can drive excessive accumulation of lipids and their derivatives, leading to a state of lipotoxicity that augments pro-inflammatory signals to promote accumulation and activation of macrophages [9], [10].
As a pro-aging determinant and as discussed above, p53 might drive excessive apoptosis and/or cellular senescence.
On the other hand, vagus nerve activity appears to drive excessive eating behavior in satiated rats when they are stimulated by norepinephrine 51.
28 For example, thoughts that tasks must be done perfectly, with feelings of failure if they are not, may drive excessive work patterns, leading to fatigue.
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9 A 55% increase in nocturnal hepatic glyconeogenesis drives excessive glucose production, favoring fasting hyperglycemia and β-cell decompensation.
Inflammatory pulmonary oedema develops when lung capillary transmural (internal minus external) pressure drives excessive fluid filtration through a disrupted, highly permeable, blood-gas barrier [ 5].
An HLA Class II association supports the premise that PHFM patients carry an underlying idiosyncratic predisposition that drives excessive fibrous proliferation when provoked by exposure to H. capsulatum organisms.
Often, veterans with PTSD will drive with excessive caution — or stop driving altogether.
The greater proinflammatory response of DCs to clinical isolates with non-haemolytic pneumolysin may drive an excessive lung inflammation as observed in post-pneumonic empyema.
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