Sentence examples for drive efficacy from inspiring English sources

The reality is that advertising has got to become more integrated with content in order to drive efficacy.

This observation also addresses one of the shortcomings thought to limit the potential of β-lactams for the treatment of human TB, i.e., the likely requirement for multiple daily administrations covering extensive periods of time (T>MIC) to drive efficacy.

Such a relationship provides a situation where one drug drives efficacy in an ASS1-negative cell line (ADI-PEG 20) and the other drives efficacy in an ASS1-high cell line (cisplatin), suggesting a favorable combination drug treatment.

The ability to measure efficacy in both the brain and plasma compartments in the transgenic mice allows us to probe whether total or free concentrations of compound drives efficacy.

A potential way to decouple the toxicity from efficacy is to determine if the pharmacokinetic parameters that drive toxicity differ from those driving efficacy, as has been the case with several other antibacterial agents (5 – 12).

In a similar manner, olanzapine has proven superior to risperidone and quetiapine in large, randomized clinical trials measuring time to discontinuation for any cause [ 3, 28], echoing our results and suggesting that antipsychotic adherence is often driven by efficacy.

The survival curves in ECOG1684 5 separated well before a year, the planned duration of treatment, raising the possibility that the early very high dose component of the regimen drives its efficacy.

The question of whether time or concentration drives the efficacy of a given drug has been used to enable the selection of dosing regimens that optimize clinical efficacy while suppressing the emergence of resistant organisms, as well as to determine clinically relevant susceptibility breakpoints (12).

Our data suggest that the tested 5-oxo-ETE derivatives (i) insert quickly into the membrane, (ii) access the receptor via transmembrane helices (TMs) 5 and 6 from the membrane side and (iii) drive potency and efficacy by differential interaction with TM5 and 7. Most importantly, we found that the methyl ester of 5-oxo-ETE (1a) showed even a higher maximum response than the natural agonist (1).

Theoretically, the major factors expected to drive the relative efficacy of an inhaled corticosteroid are potency, device efficiency (delivered lung dose) and pulmonary residency time.

There has also been a continued interest and effort in the field to utilize immune co-stimulatory molecules to further drive the potential efficacy of DNA vaccines and immunotherapeutics.