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Building from this analysis, the lambda lysis-lysogeny decision now serves as a paradigm for how intrinsic molecular noise can influence cellular behavior, drive developmental processes, and produce population heterogeneity.
These notions purport to explain how selection can drive developmental responses to environmental demands to become less dependent on the presence of the external stimuli, and become increasingly hereditary.
Alternatively, regulated periods of imbalances between turnover events (proliferation, differentiation and loss) drive developmental and adaptive changes in the epithelial tissue architecture and function.
In the description and modeling of regulatory networks that drive developmental pattern formation, an over-simplified approach in terms of the genes involved and their interactions causes a misleading "circuitry".
Most notably, changes in oxygen levels drive developmental heterochrony, with the timing of several morphological processes showing distinct scaling behaviors.
These findings prompted us to test if autophagy drives age-related epidermal morphology changes since autophagy can drive developmental [ 38] and physiological remodeling of tissues [ 39].
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Selman, M., López-Otín, C. & Pardo, A. Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis.
O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J. B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.
Quantitative characterization of the molecular signatures of infection will redefine our understanding of host response driven developmental changes during pathogenesis.
A future work will be to more thoroughly compare vector field embryogeny against graph driven developmental systems, in terms of both, evolvability and computational effort.
The same pathway, which drives developmental growth, later drives aging and its associated diseases.
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