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However, it remains to be shown whether altered histone modifications can drive altered gene expression later in development.
Recently, transgenic animals with alterations specifically targeting the urothelium (urothelial restriction or conditional transgenics) have been developed to test the hypothesis that urothelial dysfunction can drive altered bladder function.
The disorder presents delusions and hallucinations, reduced interest and drive, altered emotional reactivity and disorganized behavior [ 2].
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Such studies have led to an understanding that induction of HIF-1 responsive genes drives altered cellular metabolism, increased vascular mass and diameter and increased oxygen carrying capacity of the blood; all events which are conducive to an adaptive response to diminished oxygen supply [1], [14] [16].
Although there is evidence to suggest that changes in the steroidogenic enzyme transcriptional profile helps cancer cells to proliferate in the low-T environment, it is unclear what drives altered transcriptional regulation of these genes in CRPC.
Box 2. Could gene drives alter domesticated animals or crops?
Box 1. Could gene drives alter human populations?
With reference to the data reported in the studies mentioned above, we can deduce that in DMSXL mice the afferent feedback is reduced and the regulation of respiratory drive is altered, whereas the generation of breathing rhythm is probably not affected.
The many malignant-like phenotypes observed upon loss of a single polarity regulator must be driven by altered gene expression.
These findings suggest that the majority of differences between preM and postM breast tumors are driven by altered hormone levels, and thus areonly observed in ER+ disease.
As suggested by organ weight analysis, differences in body weights were driven by altered body composition and in particular by drastically reduced fat in M/Mt-CK−/− mice.
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