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In this publication, tiered testing strategies are proposed for non-relevant metabolites, when drinking water concentrations >3.0 μg/L will occur.
Ferrous lactate treatments corresponding to 0, 2, 5, and 12.5 mg/kg drinking water concentrations were delivered through the abomasum at 10 L/d to 4 lactating dairy cows over 4 periods (1 wk infusion/period) in a Latin square design.
Predicted drinking water concentrations were combined with default water intake rates to estimate drinking water exposures.
The study was conducted in Iowa, where some areas have high drinking water concentrations of arsenic.
Arsenic-contaminated drinking water concentrations range from < 10 μg/L to > 300 μg/L.
Moreover, uncertainties regarding drinking water concentrations may not be adequately captured by our prior distribution.
Similar(27)
Therefore, for "non-relevant metabolites" whose drinking water concentration is below 3.0 μg/L, no toxicity testing is necessary.
A January 2002 EPA draft report recommended a drinking water concentration of 1 part per billion (ppb) as safe for human health, whereas DOD says the number is likely to be much higher.
Drinking water concentration was reported at time of enrollment.
The median drinking water concentration for the 47 tube wells sampled was 1.6 μg/L (range, < 1 450 μg/L).
We found a tight correlation between the drinking water concentration and BPb levels (Table 1) that was similar to our observations in rats (Cory-Slechta et al. 1997).
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