Exact(1)
The region on chromosome 1 ranges from D1S1613 at 64,007,000 bp to D1S2624 at 154,898,000 bp (according to HapMap build 36) and encompasses a variety of overlapping linkage signals to alcohol-related phenotypes, including alcohol dependence, heavy drinking, sensitivity to alcohol, and tolerance, across a number of samples [ 17, 18, 33- 38].
Similar(59)
The full AUDIT and three item AUDIT-C questionnaires are effective in screening for harmful drinking levels (sensitivity 51-97%, specificity 78-96%) [ 24- 26], and can be used to assess alcohol consumption against current Australian national guidelines with very minor modification, i.e. to specify 4 rather than 6 drinks as representing 'at-risk' alcohol consumption.
Furthermore, our results support previous findings of beneficial effects of alcohol drinking on insulin sensitivity and HDL cholesterol levels [9] [11].
This screening question has been found to have high specificity (from 79%to96%6%) for detecting drinking problems, and sensitivity ranging from 45% to 83% [ 17- 20].
If the contamination levels of AgNPs in food will be established in the same range as for silver ions in drinking water, the sensitivity of the hMT1A-sensor described here should be adequate for screening purposes.
We have performed a series of experiments to investigate how the genetic deficiency in ALDH2 affects the behavioral pattern for alcohol drinking and the sensitivity of peripheral lymphocytes to the induction of chromosome alterations by exposure to alcohol and alcohol-related chemicals.
Dental fluorosis is sensitive to even small changes in fluoride exposure from drinking water, and this sensitivity is greater at 1 3 years of age than at 4 or 5 years (Burt et al. 2000).
They also said that coffee drinking might improve insulin sensitivity and the function of β-cells, which store and release insulin.
No questions regarding alcohol consumption were addressed to adolescents, given the cultural sensitivity of drinking in this age group and the fact that the interview took place in the presence of the parent.
Because of potential interest in exposure to < 50 μg/L of iAs in drinking water, a further sensitivity analysis was carried out after excluding participants with lifetime average iAs concentrations above the 90th percentile of lifetime average iAs concentrations (40.7 μg/L), within the group with a sum of iAs metabolites ≥ 2.5 μg/L.
CDT had the highest sensitivity for detecting current drinking, hazardous drinking patterns and drinking more than an average 40 g alcohol per day, but these sensitivities were still poor.
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