Average drinking volume (average alcohol intake per day), usual drinking quantity (drinks per day when drinking) and frequency of binge drinking were used to predict SBP/DBP.
Binge drinking is constructed from the question "Over the past 12 months, on how many days did you drink five or more drinks in a row?" Drinking quantity measures the typical number of drinks a respondent consumes each time he or she drinks.
Alcohol consumption in the last 12 months was evaluated by the graduated frequency (GF) questionnaire [ 21], with six levels of drinking quantity (≥10, 7 9, 5 6, 3 4, 1 2 and 0.5 drink during 1 day) and nine categories of drinking frequency (almost every day, 3 4/week, 1 2/week, 2 3/month, 1/month, 6 11/year, 3 5/year, 1 2/year and never).
Two alcohol-related measures are investigated in this analysis: binge drinking and drinking quantity.
For binge drinking, drinking quantity, smoking quantity, and smoking frequency, the protective effect of 9R/9R diminishes in young adulthood.
The common pattern of lifecourse-gene interaction for binge drinking, drinking quantity, smoking quantity, and smoking frequency can be explained by the legal age for alcohol and smoking.
Both the protective main effect and the gene-lifecourse interaction effect are replicated across a spectrum of most common risky behaviors: delinquency, variety of sexual partners, binge drinking, drinking quantity, smoking quantity, smoking frequency, marijuana use, cocaine use, other illegal drug use, and seatbelt non-wearing.
The drinking pattern combined drinking quantity and corresponding frequency in the GF.
Higher drinking quantity and frequency of binge drinking were associated with higher blood pressure in men but not in women.
