The characterization of the channel process enters in the algorithm when at each time instant the state of each particle is drawn randomly from the SIR-PF's proposal distribution; that is, from, which corresponds to drawing values for,,,, and.
To examine uncertainty in model predictions as a function of uncertainty in the parameters, we conducted a global sensitivity and uncertainty analysis by drawing values for 20 model parameters from normal (Gaussian) or uniform distributions.
Simulations were replicated with randomly drawn values for the parameters environment carrying capacity (K) and net reproductive output (NRO, the expected number of offspring per female).
Each simulated replicate was generated as follows: Draw values for s (0 0.1), initial admixture proportions (Tlatemaco 0.5 0.72, Calnali 0.18 0.5), number of generations of selection (Tlatemaco 40 70, Calnali 20 50), and hybrid population size (50 5000).
Then, for each person in the ESCA, that is not present in the EXCA survey, the fitted regression allowed us to draw values of height for 10106 individuals.
Chance-constrained optimization can be emulated by repeatedly solving the fixed constraint (deterministic) optimization problem in which the constraint parameters (Ca p j u or Ca p j d ) are set to randomly drawn values using a MC sampling procedure for each instance of the problem.
Draw values for s (0 0.1), initial admixture proportions (Tlatemaco 0.5 0.72, Calnali 0.18 0.5), number of generations of selection (Tlatemaco 40 70, Calnali 20 50), and hybrid population size (50 5000).
Each randomly drawn value provided the rate for the bottom-level Poisson process generating torque spikes.
From the stationary distribution of telomere length, we drew 32 values for the 32 telomeres and repeated it 10,000 times.
To explore the parameter space, we drew 1662 values for all kinetic rate parameters (kon, koff, kcat) from a distribution of 20%too 500% of the original parameters, and calculated R C,S and d S for the corresponding models, relative to an improved signal distribution from 1nM to 1µM.
