All three reviews came to essentially the same conclusion: that there was no clear evidence of fraud in the research but that there were irregularities in the record-keeping that cast doubt on the validity of the scientific results and on the conclusions drawn from the experiments.
Some major conclusions are drawn from the experiments on SUCR-DTW, ESUCR-DTW, and ISPRING, and another method of similar search over time-series streams, as follows.
First, the lessons that the policy makers drew from the experiments (of course combined with other types of input) were that early intervention was beneficial for newly unemployed, and second, that meetings were presumably a more cost effective tool compared to other types of interventions.
Although TUNEL analysis at sequential stages of development between 16hpf and 30 hpf did not reveal detectable differences in melanophore cell death between mutant and wild type embryos (data not shown), there are several factors that prevent conclusions to be drawn from the experiments.
There are two main conclusions that can be drawn from the experiments reported here.
We agree with the reviewer that the key conclusions drawn from the experiments presented in the initial submission required further validation.
There are two major concerns about the generality of the conclusions drawn from the experiments reported in this paper, both of which have to do with the nature of the DNA construct used.
The conclusion was drawn from the experiments indicated that a drug would show its therapeutic effect when it was prescribed to patients with the correct indications, while it might produce deleterious effects in individuals as result of incorrect indications [ 27].
For this reason, we have limited any conclusions drawn from the experiments to their ability to inform us on the oligomer's architecture (which we believe remain valid in the face of corrupting over-expression), but have refrained from assigning any physiological significance to these experiments.
The experiments addressing the role of HGF in activating MET signaling to bypass EGFR inhibition provide a more detailed exploration of this mechanism in one specific cancer type scenario, and support the larger conclusion drawn from the experiments we chose for replication.
Nevertheless, since our objective is to understand the impact of post treatments and the changes are usually normalized to the original value, the trends and conclusions drawn from the experiment should not be affected.
