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The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs.
Although these compounds have demonstrated beneficial clinical effects, there are some drawbacks relating to their use.
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Drawbacks related to water vapor still remain and need to be addressed.
The United States requires patients injured by medical negligence to seek compensation through lawsuits, an approach that has drawbacks related to fairness, cost, and impact on medical care.
However, some drawbacks related to premature debonding of the FRP composites from the bonded substrates have been identified.
However sonoelectrochemistry has suffered a few drawbacks related to reproducibility, scale-up and design aspects which have slowed its development.
We conclude that providing people with relevant information on possible drawbacks related to undergrounding is a necessary precondition for informed decision-making in the context of grid expansions.
However, this process suffers from several inherent drawbacks related to energy-intensive and environmentally unfriendly processing steps such as catalyst and product recovery, and waste water treatment.
While SRS-OS has certain statistical advantages, there are drawbacks related to the available sampling schemes and the accuracy and precision of the resulting value.
To overcome drawbacks related to repeated opioid administration during the treatment of chronic pain, several controlled-drug delivery systems of opioids have been designed.
However, some drawbacks related to the epoxy (hence, organic) matrices of Fiber-Reinforced Polymers (FRP) have been solved by inorganic ones yielding to novel fibre reinforced composites.
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