To overcome these drawbacks, small peptide-based compounds have been considered as carrier molecules to selectively deliver compounds to tumor specific receptors [7], [8].
For the most part, the drawback for small operators has been the historical requirement to allocate rooms to third-party distribution channels, meaning they risked not being filled, even if the B&B got a direct call from someone looking for a room – something of limited appeal to a B&B with, say, just four rooms.
Most have one major drawback: extremely small quantities; in the case of ZMapp -- the best known -- supplies are said to be exhausted.
The latter one has the drawback that small amounts of tumour cells are automatically eliminated under specific parameter constellations.
A drawback of small wards is that fluctuations in utilization are relatively large and require more capacity.
Lotus has two experienced drivers in Heikki Kovalainen and Jarno Trulli, and they are both enthusiastic about building the team, despite the drawbacks of small size and budget.
Recent researches of image encryption algorithms have been increasingly based on chaotic systems, but the drawbacks of small key space and weak security in one-dimensional chaotic cryptosystems are obvious.
The application of nanomedicines in cancer therapy overcomes the drawbacks of small therapeutic agents including poor solubility, unfavorable pharmacokinetics, low intratumoral accumulation, quick degradation, and wide tissue distribution [ 3, 4].
5 6 Some of these drawbacks include: small sample size, short duration, use of surrogate endpoints, early stopping rules that permit cross-over to experimental therapy, lack of measurement of real clinical effects, bias towards younger patients and under-representation of patients with complex health problems.
However, this is little a drawback as bootstrapping small samples takes only a reasonable amount of time.
