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However, the main drawback of data driven approaches is the requirement of huge historical database for model development.
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A drawback of data-dependent LC-MS/MS is an intrinsic bias toward sequencing the most abundant proteins in a sample that limits the detection of less abundant proteins that may be changing in disease [ 31].
On the other hand, the authors of [24] indicated the drawbacks of data aggregation such as increased transmission time.
The present manuscript evaluates several architectures for the combination of spectral outputs from these two sensors in order to compare the benefits and drawbacks of data fusion for improving the overall identification performance.
The main drawback of the data is that it does not allow us to disaggregate our data in terms of ethnic background.4 Nevertheless, we believe that the study makes an important contribution on the grounds of the uniqueness of the sample and the robustness of the estimates presented.
But, some caution is needed because one potential drawback of aggregating data spatially is that the chance of detection can be reduced (data from unaffected areas will mask the outbreak signature, and increase the detection time) [ 21].
A drawback of genotypic data from the GBS platform is often a large proportion of missing data points across samples as genomic DNA fragments are sequenced at low depth (Elshire et al. 2011).
Though the majority of trade economists has awarded it a critical acclaim stressing that value-added global trade statistics has a high heuristic value, the major drawback of such data is the lack of analytical capacity for any statistical speculations based on such data only need to be complemented by in-depth case study analysis.
The main drawback of our data is their limitation to a single state, which has implications for both generalizability to other states and attrition (since individuals leaving the state are not observed).
Another drawback of transcriptome data are usually their short read length.
A major drawback of our data is the high amount of patients with insufficient urinary protein after extraction and dialysis.
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