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These tests are time-consuming, technically challenging, and require large volumes of freshly drawn citrated blood, which is an important drawback in studying young children.
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Event rates constitute an even more significant drawback in studies on mild-to-moderate brain injury.
Mouse models of chronic Chagas disease have fundamental drawbacks that have constrained their use in studying pathogenesis.
These figures are probably an underestimate related to drawbacks in study design, exclusions of dropouts, and publication bias and should be considered with caution.
In fact, beneficial effects of bone-acting drugs in OA are increasingly reported, but reliable conclusions regarding their efficacy are hindered by methodological drawbacks in study design [ 10].
Possible drawbacks in study design, including lack of standardized case definitions, poorly defined target populations, inappropriate dose selection and measurable outcomes, and brief study durations may have masked true underlying mechanistic effects of previously investigated adjuvant therapies for HAND in specific patient populations.
Despite the role of miR-21, miR-203 and miR-205 in cellular processes associated with cancer metastasis, clearly demonstrated when each one is studied independently, their concurrent importance in keratinocyte physiology constitutes a drawback when studying them in regard to proliferation and invasion in the context of squamous cell carcinomas.
Another drawback in this study is the absence of genetic information concerning the study subjects.
The major drawback in these studies is their selection bias which is common to health facility-based studies.
Guarente is quick to point out that drawback in the study, and says he doesn't believe the work offers significant support for the idea that calorie restriction can extend lifespan in primates.
To overcome this drawback, in this study, we propose a more efficient approach to solve lattice Boltzmann equation on the non-uniform Cartesian mesh.
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