These tests are time-consuming, technically challenging, and require large volumes of freshly drawn citrated blood, which is an important drawback in studying young children.
These figures are probably an underestimate related to drawbacks in study design, exclusions of dropouts, and publication bias and should be considered with caution.
In fact, beneficial effects of bone-acting drugs in OA are increasingly reported, but reliable conclusions regarding their efficacy are hindered by methodological drawbacks in study design [ 10].
Possible drawbacks in study design, including lack of standardized case definitions, poorly defined target populations, inappropriate dose selection and measurable outcomes, and brief study durations may have masked true underlying mechanistic effects of previously investigated adjuvant therapies for HAND in specific patient populations.
The major drawback in these studies is their selection bias which is common to health facility-based studies.
First, recall bias is a drawback in case control studies.
A drawback in all studies related to LaeA/LAE1 function so far, however, is that the respective loss-of-function and overexpressing mutants display different growth rates.
A major drawback in these studies is they are limited to discriminating between CRC patients and healthy individuals, leaving aside precursor lesions and not including in the control cohort individuals with benign pathologies.
One drawback in these studies is that the dose of RT delivered would be considered suboptimal by today's standards, and therefore would ADT provide benefit in current patients receiving higher radiation doses?
The major drawback in these studies was that surgery was offered to the patients with the best performance status and the preferred treatment for the other patients was chemotherapy alone.
