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The large hexaploid nature of the genome is a drawback in determining the complete sequence which is not yet available.
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Drawbacks in determining the Charlson index by using administrative datasets have been reported previously.
Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter.
It enables patients to record their experience of change in satisfaction and perceived blood glucose control more precisely and thus provides greater validity in determining the benefits or drawbacks of a new treatment.
Accordingly, the prediction accuracy for H3 loops is not equally satisfactory as for the other loops, an important drawback because the H3 loop is central in the binding site and therefore often essential in determining the antibody antigen interactions.
However, the requirement for the B allele frequency is a drawback in cases where it is not possible to accurately determine the heterozygous positions, for example in cell lines where the normal sample is not available.
A key drawback in heuristic clustering techniques is that it is difficult to determine the number of clusters a priori.
We see this as a drawback in our analysis.
But FHA has a major drawback, in Petrowsky's view.
This may simply be the metaphysical drawback in music criticism.
That could be considered a drawback in a camera.
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