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Given this drawback, constraining the kernel to be an orthogonal matrix may be a solution.
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Mouse models of chronic Chagas disease have fundamental drawbacks that have constrained their use in studying pathogenesis.
As a main drawback, our method is constrained by data availability on cellular fluxome and target phenotype, thus demanding some experimental effort.
Or constraining it somewhat.
Constraining time encourages quality time.
It needs constraining.
"Debt is constraining.
How are we constraining them?
As a drawback, the SVD method is not constrained to output non-negative data, which can result in a small percentage of outliers negative valued field strength data which causes numerical problems when translated back to logarithmic values.
But, as a drawback, the quaternion norm needs to be constrained, which for DCO is imposed through regulariza-tion.
However, one drawback of 2b-RAD is the read length (33 ~ 36 bp) constrained by type IIB activity.
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