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We didn't use a gradual increase of IAP, but rather a first level of 20 mmHg, commonly seen in clinical settings, and then an abrupt increase to 45 mmHg, in order to augment the impact of IAH on CNS and draw safer conclusions for this relationship.
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Our preliminary data suggest that high-frequency rTMS is not useful to treat MOH, however the small sample does not allow to draw safe conclusions.
Since these results are conflicting, further, larger studies are required to draw safe conclusions.
More evidence is needed to draw safe conclusions regarding this association.
Because of small numbers in these sub-analyses, we cannot draw safe conclusions about possible sex differences.
To draw safe conclusions on therapy-related changes in cognitive and language processing and reorganisation, it is therefore imperative to investigate behavioural and neuronal correlates of rapid improvement brought about by short intervals of therapy in chronic patients.
In vivo studies are more reliable in order to draw safe conclusions with respect to the formation of bioactive peptides following the ingestion of human milk and infant formulas.
Critical analysis of the literature shows we cannot draw safe conclusions in other myopathic conditions, partly due to methodological biases in setting up clinical trials and small sample sizes leading to lower power [ 43].
Despite the fact that the small numbers (of both the sample size and events) do not allow us to draw safe conclusions, the calculated occurrence rate of 7.1 (95% CI: 6.8 7.3) CHD events per 1000 patient-years seems rather low considering the aforementioned risk profile and the advanced age of our population sample.
Therefore, considering the available research studies, it is not currently possible to draw safe conclusions on the role of ω3 PUFA in muscle diseases and further studies are first needed to elucidate whether supplementation may be harmful in certain myopathic conditions.
Therefore, it is impossible to draw any safe conclusion regarding the true VL at the time of diagnosis in these four cases.
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