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When the sulfolipid was introduced to the cells being incorporated into the object of phagocytosis (St-Salm), apoptosis was drastically augmented.
In contrast, lower doses drastically augmented CD3-induced cell proliferation which was due to co-internalization of the receptors and sustained activation of signaling components (MAP kinases, caspases, NF-κB and cell cycle components) and resulted in upregulation of various activation markers (adhesion molecules, cytokine receptors, cytokines).
However, performing a sensitivity analysis by increasing the generation of self-reactive T cells, we found that if the Teff-Treg loop parameters are maintained within homeostatic values (healthy regime), this module can cope with such increase of self-reacting Teff, even if the amount (perturbation intensity) is drastically augmented (data not shown).
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Of note, Fernandez-Gonzalez and coworkers have shown in a recent study that disruption of ciliary function in mice drastically augments the pathology after allergen challenge [33].
However, our titration experiments revealed that low doses of the very same CD95 agonists drastically augment T cell activation and proliferation under otherwise unchanged conditions.
AMP-activated protein kinase (AMPK -activating drugs, by mimicking AMPK -activatingATP ratio in BC cells, drugsically augment the release of extracellular FASN in HER2-positive by cells [ 2].
As can be seen from Figure 2(b), the goodput performance will be drastically decreased as the BER value is augmented.
This model drastically outperforms the independent GTR model, as well as the independent GTR model augmented with the assumption of gamma-distributed rates, for a dataset of primate ancestral repeats.
Accordingly, in Mdr2 −/− cells, the kinetics of induction of cylcin D1 and cyclin A was drastically advanced in response to serum stimulation, and the levels of the induction were greatly augmented (see Figure 1C, right panel).
and augmented (1968).
Both augmented it considerably.
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