Sentence examples for drastic up from inspiring English sources

Ageing in the β-phase leads to a drastic (up to 30%) decrease of the Young's modulus and an increase of the internal friction in the martensitic phase at room temperature.

Here we report how replacement of the flexible autolysis loop of human thrombin with the homologous rigid domain of the murine enzyme results in a drastic (up to 10-fold) increase in Na+ affinity and a significant improvement in the catalytic activity of the enzyme.

The drastic up-regulation of YPMT1.34 and YPMT1.34A (more than 100-fold) is difficult to explain because no known functions have been attributed to these genes.

Accumulation of the degradation resistant β-catenin in the midbrain and rhombomere1 leads to drastic up-regulation of the expression of Wnt target genes, including Drapc1, Axin2 and Tcf1.

The fast and drastic up-regulation of two of the LHCX's and also two of the LHCR's at this early time-point are in sharp contrast to the decrease in transcription level observed for almost all other genes encoding diatom antenna proteins, implying different roles for these proteins in protection and acclimation to HL (Figure 3).

Bortezomib primarily achieves this through drastic up-regulation of Noxa protein expression, though agents that promote Mcl-1 protein loss in the absence of Noxa up-regulation should have a similar effect.

Also, the drastic up-regulation of the four genes should not represent a downstream response to SI, since these genes are already differentially regulated in SCC before SI occurs.

Among them, a novel F-box gene showed a drastic up-regulation both in laser microdissected stylar canal cells and in self-pollinated whole styles with stigmas of 'Comune' in concomitance with the arrest of pollen tube growth.

Whereas cell-wall metabolism enzymes (the autolysin lytM, and several amidases lytA, sgtA and SA1759) showed drastic up-regulation, transpeptidase, acid techoic synthesis genes, the mur operon and several cap genes showed massive down-regulation after internalization (additional file 3).

This drastic up-regulation, and the absence of identical ESTs in databases support the high specificity of this gene and point out to its possible involvement in highly specific proteolytic events occurring in the style during the self-incompatible response.

Conversely, in the presence of NANOS2-ZM, we found drastic up-regulation of activated caspase-3 in Nanos2-null male gonocytes, indicating that these cells undergo more rapid apoptosis than that of Nanos2-null male gonocytes without NANOS2-ZM (Fig. 3F).