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Furthermore, knockdown of TF, FVII and PAR2 by means of small interfering RNA (siRNA, 30 nM) leads to a drastic significant increase in protein expression of LC3A/B-II.
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"That is the most drastic and significant change after what we now perceive as the dangerous murkiness of the Kohl system".
A drastic and significant decrease in tumour activity concentration, however, was observed when unlabelled 2 was co-administered, to approximately 1.0 %ID/g (p = 0.007).
A more drastic and significant change in the lag time of approximately 4 hours occurred at a temperature of 57°C, while at this temperature no significant loss of CFU was observed.
Both VEGF- C and VEGF-D gene expressions showed a drastic and significant down-regulation in both OM and SC from OB/H-IR and OB/L-IR subjects compared to leans.
We considered that the steady low incidence of meningococcal meningitis as well as the drastic and significant reduction of Hib meningitis in small children achieved during 1999 in Cuba, may have contributed to an increase of pneumococcal meningitis in 1999 and 2000, especially in children under 6 years old.
China's biogas production is currently undergoing a process of drastic transformation, with significant regional differences and sector disparities.
A less drastic (but not significant) reduction in the primary root length was observed with the cyanide synthase (ΔhcnB) mutant (PAO6344) of P. aeruginosa (Figure 1A&B) and CHAO77 (ΔhcnABC) of P. fluorescens.
With either WGO schedule there was a drastic and statistically significant reduction in the number of recombined neurons in the DRG (Fig. 6a, b).
Less drastic but still significant diminution of the energy-transducing NDH-1 activity was observed for the mutations of Asp325 to Ala or Glu, which has ionic interaction with His224.
Expressing h-oACHE-S, which contained the native 5'-proximal sequence (with the rest optimized), resulted in a drastic and highly significant (P < 0.0001) drop in the expression level when compared to the fully optimized sequence, but expression level was still modestly higher than for hACHE-S.
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