Sentence examples for drastic regulation from inspiring English sources

"Falls in income concentration due to economic downturns are temporary unless drastic regulation and tax policy changes are implemented," Mr. Saez said in his analysis.

In addition to biological consequences of RBP-J-mediated regulation, we also sought to investigate molecular mechanisms by which RBP-J regulated M2 gene expression especially expression of Arg1 given its role as a critical M2 effector molecule and its drastic regulation by RBP-J at the protein level (Fig. 4A).

Among the tested clusters (data not shown), only clusters 12 and 27 showed a drastic regulation.

Possibly about the 10th century the woodlands achieved their widest expansion, and the cultivation of irrigated lands was encouraged by means of drastic regulations, which, however, were favourably received.

Finally, treatment of cells with HB-19 and Nucant constructs results in a drastic down regulation of surface/cytoplasmic nucleolin without affecting nuclear nucleolin.

Consistent with its higher activity as an antagonist of surface nucleolin, N6L treatment causes a drastic down regulation of surface but not nuclear nucleolin in a dose dependent manner.

At higher fold-changes, there are also more transcripts up-regulated in tail fragments compared to head fragments between 12 and 36 hours suggesting that tail fragments undergoes a more drastic expression regulation during the divergence than head fragments.

Among all the miRNAs that were examined, miR-205 was identified as the most downregulated one by quantitative reverse transcription PCR (qRT-PCR), and level of miR-205 expression was found suppressed about 80% as compared with that in control samples, suggesting a drastic down regulation with the maximum inhibition (P<0.001; Figure 1a).

Whereas cell-wall metabolism enzymes (the autolysin lytM, and several amidases lytA, sgtA and SA1759) showed drastic up-regulation, transpeptidase, acid techoic synthesis genes, the mur operon and several cap genes showed massive down-regulation after internalization (additional file 3).

The drastic up-regulation of YPMT1.34 and YPMT1.34A (more than 100-fold) is difficult to explain because no known functions have been attributed to these genes.

The reactivation of the LKB1-AMPK-mTOR pathway under low energy conditions by the inhibition of BRAF signaling led to a more pronounced effect that included a drastic down-regulation of Mcl-1 (Fig 6).