Exact(8)
Treatment of S. muris worms with bryostatin-1 leads to drastic morphological changes in the mouth parts, anus, and cuticle of 90% of the 10 examined worm.
Light and scanning electron microscopy revealed normal appearance of worms collected from the infected groups with S. muris and untreated by bryostatin-1, while those collected from the bryostatin-1 treated rats revealed drastic morphological changes in the mouth parts, anus, and cuticle of all treated worms.
Inhibition of ERK signaling in control cancer cells by U0126 treatment (Fig. 8B vs 8A) or a dominant-negative form of MEK-1 (Fig. 8D vs 8C) induced drastic morphological changes similar to those obtained under LRP-1 silencing.
However, these models do not take into account effects of cell division and spatial restrictions of the meristem and, accordingly, cannot explain the derivation of morphological features such as homeostatic control despite cell proliferation in the wild type and drastic morphological changes in clv and wus mutants.
Upon stimulation with the chemokine SDF-1α, the lymphoblasts underwent drastic morphological changes and acquired a polarized cell shape displaying leading edge and uropod regions with β-tubulin staining observed now more prominently at the base of uropod regions (Fig. 1a).
Induction of Snail expression coincides with drastic morphological changes in cultured epithelial cells.
Other drastic morphological changes included presence of many vacuoles with unknown content, probably of lipid origin.
During the earliest stages of development, metazoan embryos undergo drastic morphological changes and transcriptional reprogramming.
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