Sentence examples for drastic modulation from inspiring English sources

Alteration of the strength of AFD and AWC signals led to significant changes of AIY activity, resulting in drastic modulation of behaviour.

Alteration of the strength of EAT-4-dependent AFD and AWC glutamate signals onto AIY leads to significant changes of AIY activity, which, through EAT-4-dependent glutamate signals from RIA, results in drastic modulation of thermotaxis.

One important implication of our work is that identifying and reconstructing a "youthful" stem cell niche may have long-term beneficial effects on tissue regeneration, in contrast to drastic modulation of a single cell-fate regulatory pathway, that could have deleterious side effects by promoting oncogenic transformation and/or inducing cellular senescence [ 14].

Additionally, in RASSF9−/− keratinocytes there was a drastic down-modulation of terminal differentiation markers, which could be rescued by infection with a recombinant adenovirus, Adv/HA-RASSF9.

However, the observed in vitro difference in the transporters' sensitivities to [Na+]e may not in itself be sufficient to explain the drastic sensitivity of taurine release to isoosmotic modulation of the [NaCl] observed in vivo.

The downstream biochemical effects of altered innervation patterns on neuromuscular modulation are clearly reflected by drastic changes in the concentration levels of muscle proteins.

The modulation of PvTIFY10C resulted in drastic changes in the transcript profiles of different processes in the regulation overview; silenced roots showed 179 up-regulated and 85 down-regulated ESTs, while over-expressing roots showed 54 up-regulated and 221 down-regulated ESTs (Additional file 5).

Similar modulations of Pbx2 expression revealed drastic and opposite effects in normal versus leukemic cells.

Thus, a change in one physiological regulatory event, in this case the disrupted modulation of the LCC, cannot easily induce drastic changes to the overall function of the myocyte.

These results also demonstrated that modulation of the AIY activity by opposite glutamate signals from AFD and AWC induces drastic changes in behavioural output.

However, drastic redistributions of MDM2 from p53 to the IGF-1R can probably only be achieved after experimental modulations, like inhibition of p53 expression by antisense strategies, etc, and do not likely occur in this manner in a physiologic context.