In each strain producing the long transcript, we observed a drastic reduction in Atg31p levels.
Therefore, genes belonging to essential ancient gene networks, which optimized their roles early in evolution, are expected to present high conserved components across a species tree as well as few drastic modifications in the course of their evolution.
Behavioral theory also suggests that small changes (i.e. gradual shaping of new behaviors with small incremental changes toward a goal) should be easier to initiate and maintain than larger behavior changes since they represent less drastic modifications in behavior [ 17].
The acute distinction between the stages makes the staging unrealistic since the drastic modification in treatment based on a change of stage may be based on a slight shift around the stage boundary.
Recently, in a meta-analysis of the published data concerning HER2 status stability among primaries and metastases, Carlsson et al (2004) confirmed that there was no drastic modification in HER2 status between primary tumours and their locoregional lymph node metastases and their distant visceral metastases.
Note that these samplers are all able to execute drastic network modifications in a single step and also showed superior performance even for small sample sizes.
However, in some cases such drastic modifications result in deteriorated strain performances, as the resulting flux distribution of such an intervention might not be optimal anymore, due to the interplay of the metabolic pathways in the producer strain.
But a drastic change in a short amount of time will undoubtedly have drastic unintended consequences.
As a result, drastic modifications can occur in the form of layer restructuring (Es-, F3 layers etc)., large total electron content (TEC) enhancements, equatorial ionization anomaly (EIA) latitudinal expansion/contraction, anomalous polarization electric fields/vertical drifts, enhanced growth/suppression of plasma structuring, etc.
