Therefore, genes belonging to essential ancient gene networks, which optimized their roles early in evolution, are expected to present high conserved components across a species tree as well as few drastic modifications in the course of their evolution.
The acute distinction between the stages makes the staging unrealistic since the drastic modification in treatment based on a change of stage may be based on a slight shift around the stage boundary.
Recently, in a meta-analysis of the published data concerning HER2 status stability among primaries and metastases, Carlsson et al (2004) confirmed that there was no drastic modification in HER2 status between primary tumours and their locoregional lymph node metastases and their distant visceral metastases.
Since the head undergoes drastic modifications in a few hours of growth, we registered the time-lapse reconstructions onto a reference system based on the fish anatomy; the positions of the eyes were automatically detected at each time point (supplementary material Methods) and used as landmarks (supplementary material Fig. S6 and Movie 6).
This is particular significant as several recent studies indicate that perturbation of cilia formation or function observed in several genetic diseases results in drastic modification of the cell cycle [38].
These drastic modifications in appearance and physiology require massive histolysis and histogenesis.
Behavioral theory also suggests that small changes (i.e. gradual shaping of new behaviors with small incremental changes toward a goal) should be easier to initiate and maintain than larger behavior changes since they represent less drastic modifications in behavior [ 17].
The observed differences can be explained by drastic modification of the ligand field states due to the fluoride binding.
This review describes how minor ligand modifications can result in a drastic change in the metal metal interactions in multinuclear compounds.
Open-ACRE is extensible in that future models can be added without drastic modifications to the base system.
Use of fluorinated components instead or along with standard phospholipids in film, vesicle, bubble and emulsion engineering, can cause drastic modifications of the formation processes, structure and dynamics, and functional behavior of these systems.
